Painful Terminal Neuroma Prevention by Capping PRGD/PDLLA Conduit in Rat Sciatic Nerves
نویسندگان
چکیده
منابع مشابه
Mechanisms of Nerve Capping Technique in Prevention of Painful Neuroma Formation
Nerve capping techniques have been introduced as a promising treatment modality for the treatment of painful neuroma with varied outcomes; however, its exact mechanism is still unknown. RhoA is one of the members of the RAS superfamily of GTPases that operate as molecular switches and plays an important role in peripheral nerve regeneration. Our aim was to investigate the structural and morphol...
متن کاملPrevention and management of painful neuroma.
Painful neuroma is a common sequela of peripheral nerve injury which is usually resistant to pharmacologic treatment and requires surgical intervention. The widely accepted methods of neuroma management prevent regrowth of nerve fibers, thus precluding any functional repair. The present study reviews the currently used methods and experimental approaches to prevent and cure neuromas developing ...
متن کاملAlpha-lipoic acid loaded in chitosan conduit enhances sciatic nerve regeneration in rat
Objective(s): To investigate the effect of topical administration of alpha-lipoic acid into chitosan conduit on peripheral nerve regeneration using a rat sciatic nerve transection model. Materials and Methods: Forty five Wistar rats were divided into three experimental groups randomly. A 10-mm gap of sciatic nerve was bridged with a chitosan conduit following surgical preparation and anesthesia...
متن کاملTreatment of painful peripheral neuroma by vein implantation.
Painful neuromas form on cutaneous nerves as a result of trauma, pressure, stretch or entrapment. Since the earliest descriptions of neuromas, proposed treatments have been met with poor results and controversy. The myriad of treatments described include: simple division of an affected nerve, implantation into muscle or bone, silicon sleeves and caps, repeated injection of steroids, end-to-side...
متن کاملalpha-lipoic acid loaded in chitosan conduit enhances sciatic nerve regeneration in rat
objective(s): to investigate the effect of topical administration of alpha-lipoic acid into chitosan conduit on peripheral nerve regeneration using a rat sciatic nerve transection model. materials and methods: forty five wistar rats were divided into three experimental groups randomly. a 10-mm gap of sciatic nerve was bridged with a chitosan conduit following surgical preparation and anesthesia...
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ژورنال
عنوان ژورنال: Advanced Science
سال: 2018
ISSN: 2198-3844
DOI: 10.1002/advs.201700876